Radio indium and gallium labeled porphyrins for medical imaging
Identifieur interne : 00FF68 ( Main/Repository ); précédent : 00FF67; suivant : 00FF69Radio indium and gallium labeled porphyrins for medical imaging
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Abstract
In vitro and in vivo studies have shown that porphyrins-a family of closely related compounds localize in tumor tissue and proliferative smooth muscle cells. These compounds are photosensitive and are widely used in photodynamic therapy. These ring like molecules-macrocycles contain a central cavity and bind a variety of cations including transitional elements. Some of the related compounds have been labeled with In-111, Ga-67/68 and utilized for imaging tumor and atherosclerotic lesions. We labeled coproporphyrin, a well defined single molecule, with In-111 and used it to image atheromatous plaques in rabbits. © 2001 American Institute of Physics.
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